Kev kho cov pob txha ib txwm muaj xws li titanium implants thiab autologous pob txha grafts muaj kev txwv rau kev kho cov pob txha loj, uas ua rau cov pob txha nyob ib puag ncig muaj kev puas tsuaj. Txhawm rau daws cov teeb meem no, BioStruct project tab tom ua haujlwm ntawm bioresorbable implant rau cov pob txha-phooj ywg ntau dua los kho.
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△ Lub 3D luam ntawv zinc-magnesium alloy tsim los ntawm RWTH Aachen University hauv lub teb chaws Yelemees, tus qauv mandible ua los ntawm PLA yog ua ke nrog cov tsis xws luag-matching cog ua los ntawm ZnMg
Thaum Lub Peb Hlis 20, 2023, Antarctic Xyooj tau kawm tias yog ib feem ntawm BioStruct project, RWTH Aachen University hauv lub teb chaws Yelemees tab tom kawm txog zinc-magnesium alloy tshiab ua ke rau cov qauv lattice. Lawv ntseeg tias laser beam hmoov txaj fusion (PBF-LB) yog tib txoj kev muaj peev xwm ua tau cov qauv no.
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△ Zinc-magnesium alloy lattice qauv tsim siv PBF-LB thev naus laus zis, nrog rau kab kab ntawm 200 μm
Laser beam hmoov txaj fusion, kev cia siab tshiab rau cov neeg mob tshwj xeeb cog?
Laser beam hmoov txaj fusion qhib cov kev xaiv tsim tshiab rau cov cog cog uas tuaj yeem ua tau raws li cov neeg mob xav tau xws li kev ntxhov siab thiab kev ua haujlwm corrosion ntawm qhov chaw thov. Siv lub lattice qauv tsim mus kom ze, lub geometry thiab kev npaj ntawm lub lattice hlwb raug tsim parametrically raws li cov kev cai. Cov txheej txheem lattice tau raug kho raws li qhov chaw ntawm cov pob txha tsis zoo thiab npaj rau kev tsim khoom siv PBF-LB txheej txheem.
Hauv txoj kev tshawb no, cov kws tshawb fawb tau ua tiav cov nplej ua kom zoo thiab tsom mus rau kev hloov kho microstructural los ntawm kev ntxiv me me ntawm magnesium rau zinc. Lawv tau tsim thawj lub lattice qauv siv zinc-magnesium alloy, uas tau pom tias yuav ua tau zoo thiab rov tsim dua li lub puab tsaig cog. Lub lattice qauv siv nyob rau hauv lub demonstrator muaj ib tug ncej txoj kab uas hla ntawm 200 μm.
Cov txiaj ntsig kev tshawb fawb ntawm BioStruct project yuav raug siv rau kev tsim cov khoom cog, tsim raws li kev paub tau los ntawm kev tsim khoom thiab biocompatibility ntawm zinc-magnesium alloy implants. Tsis tas li ntawd, cov txheej txheem tsim qauv kuj tseem yuav ua kom zoo dua qub thiab automated.
Nws tuaj yeem suav tau tias RWTH Aachen University pab pawg hauv tebchaws Yelemes tab tom tsim cov khoom siv- thiab tom qab ua tiav-cov ntaub ntawv tshwj xeeb, nrog rau cov ntawv thov tshwj xeeb, kom tau txais kev sib koom ua ke ntawm tus neeg mob thiab cov kev xav tau ntawm kev tsim khoom rau hauv cov txheej txheem tsim. Lub hom phiaj tseem ceeb ntawm txoj haujlwm yog los tsim cov kev cai tsim, bioabsorbable implants uas ua tau raws li cov neeg mob tshwj xeeb thiab tso cai siv cov kev kho mob maj mam.
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△ Delft cov kws tshawb fawb siv cov hlau ntxeem tau rau 3D luam biodegradable pob txha cog
Ua ntej ntawm pob txha cog los ntawm 3D luam ntawv
Siv extrusion-raws li 3D luam ntawv, engineers ntawm Delft University of Technology tau tsim porous hlau biodegradable implants nrog zoo peev xwm los hloov cov pob txha. Cov kev cog qoob loo ib ntus no tuaj yeem nqus tau los ntawm lub cev, pab txo qhov kev pheej hmoo ntawm kev mob mus ntev, thiab tso cai rau kev tsim thiab tsim cov txheej txheem ntxeem tau uas kho cov pob txha tsis zoo.
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△ Cov kws tshawb fawb tau ua haujlwm siv 3D tshuab luam ntawv thiab cov ntaub ntawv zoo li gel uas muaj cov cell nyob los luam cov pob txha zoo li
Tib lub sijhawm, cov kws tshawb fawb ntawm University of New South Wales (UNSW) hauv tebchaws Australia tau tsim cov thev naus laus zis tshiab uas tuaj yeem 3D luam cov pob txha zoo li cov hlwb uas muaj sia nyob, nrog rau cov kev siv hauv cov pob txha engineering, qauv kab mob thiab tshuaj xyuas tshuaj. Cov thev naus laus zis siv cov tshuaj pleev xim ceramic uas tuaj yeem raug extruded ncaj qha rau hauv cov cheeb tsam cuam tshuam los pab txhawb kev tsim kho ntawm cov pob txha mos thiab pob txha. Qhov kev tshawb pom, ua los ntawm kev koom tes nrog Associate Professor Kristopher Kilian thiab Dr Iman Roohani los ntawm UNSW's School of Chemistry, ua rau kev luam tawm ntawm cov cell-filled 'skeletons' ntawm chav tsev kub.
